| Publication Type: | Book |
| Year of Publication: | 1995 |
| Authors: | U. P. Ramsey, Walter, J. A., Douglas, D. J., Wright, J. L. C. |
| Publisher: | ABSTRACTS FROM THE INTERNATIONAL CONGRESS ON NATURAL PRODUCTS RESEARCH HELD IN HALIFAX, NOVA SCOTIA, JULY 31-AUGUST 4 1994., 1995, p. 220, Journal of Toxicology: Toxin Reviews [J. TOXICOL.: TOXIN REV.], vol. 14, no. 2 |
| ISBN Number: | ISSN 0731-5176 |
| Keywords: | amino acids, biochemistry, Biological poisons, biophysics, biosynthesis, Environmental Regime:, Marine, Metabolites, Pseudonitzschia pungens multiseries, Q1 01226 Physiology |
| Abstract: | Domoic acid is a neuroexcitatory amino acid responsible for an outbreak of shellfish poisoning in eastern Canada in 1987, and more recently implicated in the deaths of aquatic birds on the West Coast of the U.S.A. The Canadian source of the toxin was identified as the diatom Pseudonitzschia pungens forma multiseries. From our [1,2- super(13)C]-acetate labelling studies it appears that domoic acid is biosynthesized in the diatom from an activated citric acid cycle intermediate which condenses with an isoprenoid chain. We have investigated the timing of this event and the validity of the pathway using [2- super(13)CD sub(3)]-acetate and [1,2- super(13)C]-acetate added at different stages of the growth cycle. |